News, Analysis, Trends, Management Innovations for
Clinical Laboratories and Pathology Groups

Hosted by Robert Michel

News, Analysis, Trends, Management Innovations for
Clinical Laboratories and Pathology Groups

Hosted by Robert Michel
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Human Longevity Inc. Unleashes Power of Whole-Genome Sequencing to Unlock Keys to Healthy Aging; Research May Lead to New Clinical Laboratory Tests

Human genome pioneer J. Craig Venter’s newest project seeks to ‘change the way medicine is practiced’ by creating genomic-based medicine model

With little fanfare or public notice, a start-up company in San Diego is busy sequencing the largest number of whole human genome sequences in the world. The knowledge expected to result from this effort promises to revolutionize healthcare, as well as clinical laboratory testing.

Human Longevity Inc. (HLI) is a genomics and cell therapy company that has assembled the largest human genome sequencing operation in the world. It’s goal is to use whole genome sequencing and cell-based therapeutics to redefine aging and “meaningfully extend the human lifespan.”

“HLI’s mission is to identify the therapeutically targetable mechanisms responsible for age-related human biological decline, and to apply this intelligence to develop innovative solutions to interrupt or block these processes, meaningfully extending the human lifespan,” HLI states on its website. “We are trying to tackle some of the most vexing diseases like cancer, heart disease, and diabetes … we are working to change the way medicine is practiced through our genomic-focused, preventive model.” (more…)

Use of “Long Read” Gene Sequencing Allows University of Washington Researchers to Uncover Thousands of Never-before Seen Gene Variations

This and similar research initiatives expected to increase the number of genetic markers that would be useful for creating clinical pathology laboratory tests and therapeutic drugs

Whole human genome sequencing continues to become faster, easier, cheaper, and more accurate to do. Because of these advances, the sheer number of human genomes being sequenced is skyrocketing. This huge increase in data is helping researchers unlock many new insights that, in turn, are fueling efforts to develop useful new medical laboratory tests and therapeutic drugs.

This is happening at the University of Washington (UW), where researchers using new genome sequencing technology are uncovering thousands of never-before-seen genetic variants. The application of “long read” gene sequencing technologies is allowing these researchers to identify genetic variants previously unknown, and that are made up of between 50 and 5,000 base pairs.

The discovery is important for two reasons. First, it could close existing gaps in the genome map. Second, it could help scientists identify new genomic variations that are closely associated with difficult-to-diagnose diseases. Of interest to pathologists and clinical laboratory professionals, such discoveries could point to expanded use of genetic testing for diagnosis and treatment of disease. (more…)

Study at University of Chicago Uses Supercomputer to Shorten Time Required to Analyze Whole Human Genome Sequences; May Help Pathologists Deliver Faster Diagnoses

Achievement at University of Chicago may help clinical laboratories analyze large quantities of genomic data much faster than ever before, thus shortening the time required to produce a diagnostic result

It’s a breakthrough in the time required to analyze data from whole human genome sequencing. Researchers at the University of Chicago have successfully demonstrated that genome analysis can be radically accelerated.

This could be a big deal for pathologists and clinical laboratory scientists. That’s because a faster time-to-answer from gene sequencing would increase its diagnostic and therapeutic value to clinicians.

Faster and more accurate analysis of genomic data holds the promise of advances in patient management and greater understanding of the genetic causes of risk and disease. This could mean expanded opportunities for pathologists to engage with clinicians in the use of genomic data to inform diagnosis, choice of treatment, and disease management. (more…)

Innovative Glasses Enable Clinical Laboratory Phlebotomists to See Vasculature Through the Skin

New eyewear technology could make venipuncture easier for phlebotomists and increase patient satisfaction with that medical laboratory service

New technology now makes it possible for the wearer of a special pair of glasses to detect hidden vasculature and changes in the blood through the skin. Some experts predict that this innovative technology might be used by medical laboratory phlebotomists to improve the collection of blood—thus raising patient satisfaction with phlebotomy services.

Eyewear Technology Shows Serious Potential for Medical Use

Developed by 2AI Labs, a company based in Boise, Idaho, the glasses amplify fluctuations of oxygen levels in hemoglobin just beneath the skin. The story was reported in Technology Review. (more…)

$900 Point-of-Care DNA Nanopore Sequencer May Hit Market in Next 12 Months

Even small clinical pathology laboratories could afford this  new miniaturized gene sequencer

Is the profession of pathology  and clinical laboratory medicine ready to deal with point-of-care DNA sequencing technologies? A company in the United Kingdom says that, as early as next year, it can bring a portable high-throughput unit to market that will sell for around US $900.

Researchers at Oxford Nanopore Technologies Ltd. (ON) have developed new-generation sequencing technology that uses nanopores to deliver ultra-long, read-length, single molecule sequence data, the company stated in a press release. And it does this with competitive accuracy on a high-throughput electronic platform. (more…)