Scientists at St. Jude Children’s Research Hospital Create 3D Map of Mouse Genome to Study How Genes Respond to Disease

The scientist also employed machine learning “to gauge how easily accessible genes are for transcription” in research that could lead to new clinical laboratory diagnostic tests Anatomic pathologists and clinical laboratories are of course familiar with the biological science of genomics, which, among other things, has been used to map the human genome. But did you know that a three-dimensional (3D) map of a genome has been created and that it is helping scientists understand how DNA regulates...

New Insights into Genetic Mechanisms Common to Humans and Simpler Species May Form the Basis for New Diagnostic Tests Performed by Clinical Pathology Laboratories

Scientists participating in the modENCORE study have the goal of understanding the causes of hereditary genetic diseases in humans New discoveries about the interaction of genes and transcription factors in creating different types of RNA will be of interest to pathologists and clinical chemists performing genetic tests and molecular diagnostic assays in their medical laboratories. The goal of this research is to better understand hereditary genetic disease in humans. The new knowledge is...

Better Understanding of DNA’s ‘Dark Matter’ May Lead to Useful New Clinical Pathology Laboratory Tests

DNA ‘dark matter’ will provide clinical laboratories and pathologists with a new specimen source and new methodology for developing useful diagnostic tests Growing knowledge about DNA “dark matter” may soon make it possible for clinical laboratories to develop new assays that reveal clinical information useful in diagnosing and guiding therapeutic decisions. In genetics, “dark matter” describes the non-coding areas of DNA. Recent discoveries indicate that dark matter plays more important roles...
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