News, Analysis, Trends, Management Innovations for
Clinical Laboratories and Pathology Groups

Hosted by Robert Michel

News, Analysis, Trends, Management Innovations for
Clinical Laboratories and Pathology Groups

Hosted by Robert Michel
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Study of Cross-Contamination of Biopsy Specimens in 69 Anatomic Pathology Laboratories Raises Concerns about Test Quality and Patient Safety

Extraneous tissue cross-contamination found in all participating pathology laboratories Cross-tissue contamination, regardless of specimen volume or how frequently reagents were changed

Pathologists and histotechnologists have long known that traditional methods of processing tissue for diagnosis have the potential to cross-contaminate human biopsy specimens. This risk to patient safety and diagnostic accuracy was accepted over the decades because of the limitations of technology and inability to more precisely measure the performance of individual work processes in the histology laboratory.

In recent years, two things have begun to change this long-standing status quo in medical laboratories. These developments now make it possible to more accurately measure the performance of histology work processes. In turn, this allows an understanding of the true rate of errors that happen from the time a human biopsy specimen arrives in the anatomic pathology laboratory until the completed slides are ready to be diagnosed by a pathologist. (more…)

Revisiting the Clinical Pathology Lab’s Problem of Floaters and Other Contaminates

As automation transforms the manual work processes in the histopathology laboratory, “floaters” may become a thing of the past

Any histotechnologist and pathologist familiar with the manual work processes commonly in use in histopathology laboratories knows about “floaters.” These are the pesky artifacts that are a consequence of the common practice of manually processing tissue through the series of H&E linear baths required for the proper staining of these samples prior to analysis by anatomic pathologists.

“Floaters” are a relevant example of why manual work processes in the histopathology laboratory can be the source of errors and mistakes. Certain types of floaters—including floaters consisting of malignant tissue fragments—have the potential to contaminate the patient specimen. This can negatively impact patient safety and even contribute to a misdiagnosis of the patient. Moreover, the issue of floaters has been around for decades, because the manual work processes involving the H&E (hematoxylin and eosin stain) linear baths have remained relatively unchanged during this time.

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