News, Analysis, Trends, Management Innovations for
Clinical Laboratories and Pathology Groups

Hosted by Robert Michel

News, Analysis, Trends, Management Innovations for
Clinical Laboratories and Pathology Groups

Hosted by Robert Michel
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Whole Human Gene Sequencing Technology Is Poised to Be the Next Big Thing for Clinical Pathology Laboratories

Smaller, more affordable sequencers and genome sequence interpretation computers are catching the interest of pathologists and medical laboratory scientists

In the field of whole human genome sequencing, the technology continues to improve at a remarkable pace. Products now entering the research and clinical marketplace offer speedier, more accurate gene sequencing capabilities at prices that are within the budget reach of many clinical laboratories and anatomic pathology group practices.

Miniaturization and lower cost is driving genomic medicine ever closer to the routine clinical setting. The combination of next generation gene sequencers with a smaller footprint and advances in genomic data analysis technology mean that genomic testing will increasingly migrate to smaller lab settings. Dark Daily offers its readers a look at some of the latest gene sequencing products and what their manufacturers say about the capabilities of these gene-sequencing systems. (more…)

Study Shows Too Many Electronic Alerts Cause 30% of Primary Care Physicians to Overlook Essential Clinical Laboratory Test Results

Missed results in EHRs were related to information overload, electronic handoffs from one provider to another, and perceptions of poor usability of the EHR

Physicians often overlook important clinical laboratory test results when they get too many alerts in a day. This was one of several findings from a study designed to see how physicians responded to alerts delivered through an electronic health record system (EHR).

These findings will not surprise most pathologists and medical laboratory managers. Daily and weekly, they see how frequently “out of normal” test results can be reported to a referring physician. (more…)

Meet the World’s Largest Concentration of Hospitals, Physicians, and Clinical Pathology Laboratories

It’s in Houston, Texas, and is visited by 160,000 people every day

If someone asked you to identify where the world’s largest concentration of hospitals, physicians, and medical research institutions is located, would you know that answer? It is the Texas Medical Center (TMC), and it packs a remarkable number of healthcare providers into a very small neighborhood near downtown Houston.

This mass of hospitals, office-based physicians, and other healthcare providers may also make the Texas Medical Center one of the world’s biggest collection of medical laboratories and anatomic pathology practices. Without question, this is dream territory for sales reps who market clinical laboratory testing and anatomic pathology services.
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Understanding the Epigenome’s Role in Cancer May lead to New Clinical Pathology Laboratory Tests

Disruptive technology drops the cost of DNA methylation sequencing by 100-fold



As sequencing of individual human genomes becomes more affordable and useful, the next big hurdle in genetic science will be to map the human epigenome. While DNA provides the blueprint for building a human being, the epigenome determines the details of how that blueprint is expressed in an individual. Pathologists and clinical laboratory administrators will want to track efforts to map and understand the human epigenome.

The epigenome is a set of chemical modifications to the genome that are not encoded in the DNA but which modulate how and when genes are expressed. Methylation is only one marker in the complex epigenetic map, but it is an important one. Methylation suppresses gene activity, and is thought to be responsible for suppressing some genes that prevent cancer. Though researchers are a long way from using this knowledge to cure cancer or other diseases, faster, more affordable DNA methylation sequencing will help move that research forward.

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