News, Analysis, Trends, Management Innovations for
Clinical Laboratories and Pathology Groups

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News, Analysis, Trends, Management Innovations for
Clinical Laboratories and Pathology Groups

Hosted by Robert Michel
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Researchers, including pathologists, can use Apple’s ResearchKit app to help collect and share genetic information about cancers and other diseases while building a huge genome database

By providing tools to allow users to be more productive in working with healthcare big data, several Silicon Valley giants hope to increase their presence in medical services. The latest company to enter the field is Apple Computers (NASDAQ:AAPL). In March it announced the availability of ResearchKit, an open-source software framework that turns the iPhone into a research tool.

Pathologists and clinical laboratory scientists have a stake in the healthcare big data trend, since more than 70% of the typical patient’s permanent medical record consists of medical laboratory test data. Thus, the products introduced by Apple, Google, and other Silicon Valley firms that are designed to help physicians and other professionals work with healthcare big data have the potential to transform the way value is harvested from these data sets.

It was Google (NASDAQ:GOOG) that took the first leap into the medical research arena. Last year, it launched Google X Life Sciences to assemble a database of the human genome. (See Dark Daily, “Google Takes First Steps to Create World’s Largest Human Genome Database as Part of Wider Strategy to Become a Major Player in Healthcare ‘Big Data’” October 14, 2014).

Apple’s strategy is to support researchers. Its ResearchKit is designed to be an open-source software framework that turns the iPhone into a research tool. It enables development of apps that help medical researchers recruit study subjects and collect health information through iPhone’s sensors and surveys. Because it is an open-source platform, researchers also can create apps for Android and Windows devices.

First Five ResearchKit Apps Already in Use

Apple helped launch the first five ResearchKit apps, which offer iPhone users who suffer from specific conditions the ability to track their symptoms. Users of iPhones can also participate in research trials and surveys while allowing researchers to monitor their progress. For example:

GlucoSuccess, was developed by the Center for Assessment Technology and Continuous Health at Massachusetts General Hospital. It uses information about diet, exercise and medicine to record how different factors influence blood sugar levels, noted a Huffington Post report.

mPower was developed by Sage Bionetworks. This not-for-profit research organization, tracks symptoms of Parkinson’s disease by asking users to play games and complete dexterity exercises.

When researchers at New York’s University of Rochester used mPower to recruit participants for a Parkinson’s study, thousands of potential subjects responded within a few days. It was a powerful demonstration of the extensive reach of this platform, noted a Technology Review report.

Apple Calling the Shots in Genetic Studies Using HealthKit Apps

Apple is currently collaborating with researchers on two studies, one at the University of California San Francisco (UCSF) and another at New York’s Mount Sinai Hospital. Each study will use iPhone apps to recruit subjects and collect or test their DNA. Similar to ResearchKit apps, the research studies must be approved by both Apple and an institutional review board, which advises researchers on studies involving volunteers, noted the Technology Review story.

The UCSF study is already under way. It is researching the causes of premature birth using a combination of gene tests and other data collected on expectant mothers’ iPhones. This study is led by Atul Butte, M.D., Ph.D., a world-renown Big Data expert and new head of UCSF’s Institute for Computational Health Sciences. “The first five [ResearchKit] studies have been great and are showing how fast Apple can recruit,” he said in the Technology Review article. “I and many others are looking at types of trials that are more sophisticated,” he added, noting that the genetic causes of premature birth aren’t well understood.

Atul Butte, M.D., Ph.D

The University of California San Francisco (UCSF) recently tapped Atul Butte, M.D., Ph.D. (above), an expert in medical informatics and pediatrics at Stanford University, to head the new UCSF Institute for Computational Health Sciences. In addition to his role at UCSF, Butte also has been named executive director of clinical informatics for UC Health Sciences and Services. (Photo and caption copyright University of California San Francisco.)

DNA Study Proposed by Mount Sinai Researchers Is Under Consideration

To participate in studies involving DNA, participants must agree to have a gene test. This requires a specimen, such as saliva, be sent to an Apple-approved gene-sequencing lab, which for these two studies would be UCSF or Mount Sinai. The DNA studies target 100 or fewer medically important disease genes, known as “gene panels,” not the subjects’ entire genomes. When done in large volume, these types of test would only cost a few hundred dollars each.

Scientists will maintain study data in a cloud database. However, some findings might be displayed on participant iPhones, as well. Patients determine how much of their medical data metrics are shared on a consent screen that includes Apple’s agreement to not share patient data with third parties.

Tech Companies Plan to Free Medical Data from Privacy Constraints

An unidentified source for the Technology Review article suggested that Apple is hoping to eventually let people share their DNA data with others, including the organizers and other research projects. This would create a genome database similar to what Google is attempting to accomplish with its Baseline Study project, as reported by Dark Daily (October 8, 2014).

ResearchKit is the brainchild of Apple’s Medical Technology Advisor Stephen Friend, M.D., Ph.D., a former pharmaceutical company executive who is now President, Co-Founder and Director of Sage Bionetworks. His vision is for a “data commons” in which study subjects are active participants in scientific research—a concept Apple has embraced since 2013.

“[W]e need more data. In a traditional clinical study, you’d be thrilled to find 500 research ‘subjects,’” stated Friend. “But imagine what is possible when you can quickly and reliably activate 20,000 research ‘partners.’ Similarly, gathering data a few times per year is the traditional gold standard, so imagine the possibilities when we are able to gather data continuously, all the time. He was quoted in a University of Rochester Medical Center article.

The Technology Review report noted that Silicon Valley companies, including Google and Apple, are determined to overrun what Friend referred to as the “medical-industrial complex” with apps and mobile devices. Because hospitals and research groups are required by state and federal privacy laws to keep patient health information private, Silicon Valley tech companies are empowering patients to collect their own data—giving them control over it—with the hope that it will be shared for use in consumer apps and technologies, as well as in science.

Stephen Friend, M.D., Ph.D

Stephen Friend, M.D., Ph.D., President, Co-founder and Director of Sage Bionetworks, a nonprofit research organization, who advocates for a “data commons” in which study subjects are active participants in scientific research. He also serves as Apple’s Medical Technology Advisor. (Photo copyright Sage Bionetworks.)

HealthKit and Apple’s iOS Laid Foundation for Digital Health Movement

Apple entered the “digital health” movement last year with its “Health” app, which came bundled with the latest iPhone iOS operating system update. The Health app has fields to track 70 types of health data: including diet, blood pressure and cholesterol, steps walked or miles run.

Apple also launched the HealthKit developer platform to support third-party development of health and fitness apps that share data with iPhone’s Health app, which it displays on a dashboard. The company also partnered with IBM to develop apps that enable nurses and hospitals to monitor patients and mine medical data, as Dark Daily reported (December 19, 2014).

Digital Technology Likely to Affect Laboratory Medicine Interests

Digital technology is already invading the clinical laboratory industry with smartphone devices and apps that perform diagnostic lab tests. This is likely to have a disruptive impact on the commercial lab testing business in general.

Now with high-tech players like Apple and Google involved in generating, storing, managing, and evaluating DNA and whole-human genome sequencing, pathologists and medical laboratory scientists can expect these activities to impact medical laboratories that are focused on genome diagnostic testing at some point in the future.

— Patricia Kirk

Related Information:

Apple Has Plans for Your DNA

Apple Highlights Parkinson’s App with URMC Ties 

mPowering the Apple ResearchKit: How Max Little Put a Parkinson’s App on the iPhone

Apple Introduces ResearchKit, Giving Medical Researchers the Tools to Revolutionize Medical Studies

Apple Announces ResearchKit and 5 medical research apps launching today

Apple Helped IBM Create a Service That Can Analyze Medical Data Collected by iPhone Apps and Could Deliver Personalized Health Advice

7 Ways Apple’s New Software Could Change Medical Research for The Better

Google Health’s Pending Demise Highlights PHR Challenges for Clinical Pathology Laboratories

Google Takes First Steps to Create World’s Largest Human Genome Database as Part of Wider Strategy to Become a Major Player in Healthcare ‘Big Data’

Google’s Calico Start-up to Sequence Whole Human Genomes of Healthy 100-Year-Olds in Project to Solve Puzzle of Human Aging

Google’s Latest Healthcare Initiative is to Put Clinical Laboratory Biomarkers on Nanoparticles to Enable In Vitro Health Monitoring by Consumers