News, Analysis, Trends, Management Innovations for
Clinical Laboratories and Pathology Groups

Hosted by Robert Michel

News, Analysis, Trends, Management Innovations for
Clinical Laboratories and Pathology Groups

Hosted by Robert Michel
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Sleek ‘Lab in a Needle’ Is an All-in-One Device That Detects Liver Toxicity in Minutes during a Study, Showing Potential to Supplant Some Medical Laboratory Tests

Researchers’ prototype uses lab-on-a-chip technology and seems to do it all, from collection and analysis to results in minutes and in the palm of your hand

Here’s a diagnostic workhorse that can also easily slip inside the pocket of a doctor’s white coat. The slim device, created and reported by researchers, integrates a clinical laboratory’s workflow from collecting samples to analyzing them and reporting results in minutes.

The device is dubbed “lab in a needle” by researchers at Houston Methodist and their collaborators at Singapore’s Nanyang Technological University (NTU) and the Singapore Institute of Manufacturing Technology (SIMTech). The recently announced study focused on liver toxicity. But the research team says in a news statement that their medical laboratory-in-a-needle has potential to diagnose and monitor therapies for many health conditions in settings well beyond the medical laboratory and hospital.

For clinical laboratory leaders and pathologists, the prototype can be seen as another step forward in efforts to develop more sophisticated point-of-care testing (POCT) that incorporate miniature lab-on-a-chip (LOC) technologies. Mass production could bring the tiny mobile lab’s capabilities to remote and rural communities where low cost and ease of use are essential. (more…)

Dental Plaque Could Lead to Clinical Laboratory Testing for Biomarkers to Identify Health Risks

Researchers have found that isolating a particular gene within the oral microbiome can reveal a huge amount of useful diagnostic information about a person’s health

Most people don’t think of dental plaque when they think about clinical laboratories. For the vast majority of people, the only diseases that dental plaque bring to mind are those of the mouth:

gingivitis;
periodontitis; and,
dental caries.

Samples that are sent to medical labs and pathology laboratories are more often blood or tissue. However, that could be changing, thanks in part to the work being done at the Oral Microbiome and Metagenomics Research Lab (OMMR) at the University of Toronto. (more…)

In the UK, Pathologists Are Watching Phase II of a Clinical Trial for a Breathalyzer System That Uses Only a Breath Specimen to Diagnose Lung Cancer

If the clinical study validates this patient-friendly, non-invasive approach to diagnosing lung cancer, it could eventually mean fewer referrals of tissue biopsies to medical laboratories

For almost a decade, pathologists have seen a regular stream of news stories about technologies that utilize a sample of human breath to diagnose a disease or health condition. Now comes news that just such a diagnostic test for lung cancer is beginning clinical trials in the United Kingdom.

The clinical trials will evaluate breathalyzer technology developed by Engineer Billy Boyle, M.S., Co-founder and President of Operations at Cambridge-based Owlstone Ltd.. The clinical trials of this new breathalyzer technology to detect lung cancer are taking place at two National Health Service (NHS) hospitals: University Hospitals of Leicester and Cambridge’s Papworth Hospital in the United Kingdom.

The reason why so much research is happening in this field will be familiar to clinical laboratory managers and pathologists. Use of volatile organic compound (VOC) biomarkers in breath to diagnose disease is an ideal concept because it is convenient, non-invasive, and well tolerated by patients. However, until the start of this clinical study, researchers have explored the potential of this diagnostic approach for some time, but with limited success. (more…)

Researchers Create Nanoparticle that Targets Cancer to Optimize MRI Scanning; New Technology Has Potential to Reduce Number of Tissue Biopsies and Pathology Testing

Researchers at Imperial College London report that their new nanoparticles make it possible for cancer to be visible in magnetic resonance imaging

Even as pathologists are working to develop more sensitive and accurate diagnostic tests for cancer, similar efforts are underway in radiology and imaging. In fact, one research team has developed a self-assembling nanoparticle that can adhere to cancer cells, thus making them visible in MRI scans and possibly eliminate the need for invasive tissue biopsies.

Clinical pathologists and medical laboratory managers will be interested in this research, which is being done at Imperial College London (Imperial). Researchers there have developed a self-assembling nanoparticle that targets cancer cells and makes them visible on magnetic resonance imaging (MRI) scans. (more…)

Nanotechnology-Based Medical Laboratory Test Chip Developed at Stanford University Detects Type-1 Diabetes in Minutes and Can Be Used in Doctors’ Offices

Developers seeking FDA Approval for microchip-based nanotechnology type-1 diabetes test, which has been performed on people with accurate results

New nanotechnology has made it possible for a team at Stanford University School of Medicine to develop a medical laboratory test for type-1 diabetes that can be performed in a physician’s office and does not require a specimen collected by venipuncture.

This microchip requires just minutes to diagnose type-1 diabetes in near-patient settings, according to a Stanford University news release. (more…)

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