News, Analysis, Trends, Management Innovations for
Clinical Laboratories and Pathology Groups

Hosted by Robert Michel

News, Analysis, Trends, Management Innovations for
Clinical Laboratories and Pathology Groups

Hosted by Robert Michel
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Expanding Knowledge about the Human Microbiome Will Lead to New Clinical Pathology Laboratory Tests

With $175 Million in Funding, Human Microbiome Project is Making Rapid Progress

Research into the human microbiome is expected to trigger development of new diagnostic tests that will be offered by clinical pathology laboratories. That’s because the organisms that live on us and in us are as unique to individuals as their DNA, and scientists believe these microbes may be just as important to health. Which microbes and how much they matter to the host’s health are the questions a consortium of researchers involved in the Human Microbiome Project (HMP) hope to answer.

This five-year, $157-million project, funded by the National Institutes of Health, will sequence and classify 900 microbes believed to play a role in human health. Analysis of the sequences of the first 178 microbes, which was published in the May 21 issue of Science, held some surprises, particularly in regard to the extent and complexity of microbial diversity. About 90% of their DNA was previously unknown. The study also identified novel genes and proteins that contribute to human health and disease.

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Hospital Laboratories Pursue Higher Patient Satisfaction Scores with Innovative Services

American Society of Clinical Pathology recognizes top-performing clinical pathology labs


When it comes to patient satisfaction rankings in hospitals, the clinical pathology laboratory is often ranked at the very bottom of the 10 clinical service categories measured by patient survey systems such as Press Ganey Associates. This bottom-tier ranking is undeserved, but happens for a logical reason.

For most patients, their only interaction with the hospital’s laboratory is when a phlebotomist sticks them with a needle to collect blood. Most patients find needle sticks to be uncomfortable and unpleasant. Further, a significant number of patients are afraid of needles.

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Plasma Devices for Hand Cleaning Expected to Show Up Soon in Hospitals and Clinical Laboratories

Use of plasma technology will give healthcare workers another way to clean their hands


Even Buck Rogers and Flash Gordon would be amazed to learn that plasma technology is about to deliver a way for healthcare workers to sanitize their hands without using soap and water! Pathologists and clinical laboratory managers will be interested to learn about a novel device that bathes hands with plasma as a way to reduce the spread of microorganisms by healthcare workers, including superbugs like MRSA, an antibiotic-resistant strain of Staphylococcus aureus.

Prototypes already exist and are designed to be simple for healthcare workers to use. They would simply stick their hands into a small box that bathes the hands with plasma that is specifically engineered to zap bacteria, viruses and fungi. The plasma used in the hand sanitizer is a gas similar to that used in fluorescent lights, neon signs, and televisions, but works at room temperature and pressure.

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Pathologists Take Note: C. Craig Venter Just Created the First Synthetic Life Form

Milestone achievement may lead to more sophisticated clinical laboratory tests


Now science can create synthetic life forms and J. Craig Venter, Ph.D., is the first to do it. The landmark feat, which involved building the genome of a bacterium from scratch and incorporating it into a cell, “paves the way for designer organisms that are built rather than evolved,” noted the author of an article in guardian.co.uk.

J. Craig Venter, Ph.D., best known to pathologists and clinical laboratory scientists for his role in sequencing the first human genome, achieved the feat at the J. Craig Venter Institute in Rockville, Maryland. Venter and his team synthesized the 1.08 million base pair chromosome of a modified Mycoplasma mycoides genome. The synthetic cell, called Mycoplasma mycoides JCVI-syn1.0, is proof of the principle that genomes can be designed in the computer, chemically made in the laboratory, and transplanted into a recipient cell to produce a new self-replicating cell controlled by the synthetic genome. The experiment demonstrates how fast genetic technologies are advancing.

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UA Research Will Accelerate Development of Clinical Laboratory Blood Test for Breast Cancer

Use of synthetic antibodies and a finger prick sample of blood could give clinical laboratories new tool to screen for breast cancer


A simple clinical pathology laboratory blood test for early detection of breast cancer may be just around the corner. At the University of Arkansas (UA), researchers are building a library of synthetic antibodies called affitoids that can be used to detect breast cancer in its earliest stage.

Researchers believe they are closing in on the creation of an assay that can rapidly validate proteins secreted by microscopic breast cancer cells. “We want to implement a rapid screen that is sensitive, highly accurate, non-invasive and inexpensive,” said Shannon Servoss, Ph.D., Assistant Professor of Chemical Engineering at UA. “Such a test would be easy to use and applicable to women of all ages, races and ethnicities,” she said. “Hopefully we will be able to make the test sensitive enough so that only a finger prick [specimen] is needed.”

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